Note: Recently too busy with study, now getting to the end of semester but there are more and more stuff to read. A concluding test for therapy in end of May and summer exams fall in mid of June. (x_x)
Recently I was studying about extracellular matrix (ECM) in Biochemistry, and one thing caught my attention, that is laminin. It is a multiadhesive glycoprotein (MAG) that located in basal lamina of all epithelial cell, external laminae of muscle cells, adipocyte and Schwann cells. It has molecular weight of 140-400kDa. It is a heterodimeric protein with 3 chains. Major functions are to anchor cell surface to basal lamina (cell-ECM interaction), to provide additional structural support for tissues.
Ok, I know this geting boring, but is so special with this laminin? Let's refer some informations in Wikipedia:
Laminin is a protein found in the extracellular matrix, the sheets of protein that form the substrate of all internal organs also called the basement membrane. It is the major non-collagenous component of the basal lamina, such as those on which cells of an epithelium sit. It has four arms that can bind to four other molecules. The three shorter arms are particularly good at binding to other laminin molecules, which is what makes it so great at forming sheets. The long arm is capable of binding to cells, which helps anchor the actual organs to the membrane.
Laminin is vital to making sure overall body structures hold together. Improper production of laminin can cause muscles to form improperly, leading to a form of muscular dystrophy.
Source: en.wikipedia.org/wiki/Laminin
And how does this laminin with such a vital role looks like?
It looks exactly like a cross, Amazing isn’t it? And it is this cross that holds all the cells and tissues together in our body.
A verse to finish this post:
He is the image of the invisible God, the firstborn over all creation. For by him all things were created: things in heaven and on earth, visible and invisible, whether thrones or powers or rulers or authorities; all things were created by him and for him. He is before all things, and in him all things hold together.
(Colossians 1:15-17)
Amen.
Recently I was studying about extracellular matrix (ECM) in Biochemistry, and one thing caught my attention, that is laminin. It is a multiadhesive glycoprotein (MAG) that located in basal lamina of all epithelial cell, external laminae of muscle cells, adipocyte and Schwann cells. It has molecular weight of 140-400kDa. It is a heterodimeric protein with 3 chains. Major functions are to anchor cell surface to basal lamina (cell-ECM interaction), to provide additional structural support for tissues.
Ok, I know this geting boring, but is so special with this laminin? Let's refer some informations in Wikipedia:
Laminin is a protein found in the extracellular matrix, the sheets of protein that form the substrate of all internal organs also called the basement membrane. It is the major non-collagenous component of the basal lamina, such as those on which cells of an epithelium sit. It has four arms that can bind to four other molecules. The three shorter arms are particularly good at binding to other laminin molecules, which is what makes it so great at forming sheets. The long arm is capable of binding to cells, which helps anchor the actual organs to the membrane.
Laminin is vital to making sure overall body structures hold together. Improper production of laminin can cause muscles to form improperly, leading to a form of muscular dystrophy.
Source: en.wikipedia.org/wiki/Laminin
And how does this laminin with such a vital role looks like?
It looks exactly like a cross, Amazing isn’t it? And it is this cross that holds all the cells and tissues together in our body. A verse to finish this post:
He is the image of the invisible God, the firstborn over all creation. For by him all things were created: things in heaven and on earth, visible and invisible, whether thrones or powers or rulers or authorities; all things were created by him and for him. He is before all things, and in him all things hold together.
(Colossians 1:15-17)
Amen.
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